How Long Does Diphenhydramine Take To Work

Diphenhydramine use is associated with highly uncomfortable and/or dangerous experiences.

Deliriants are highly unpredictable and may result in erratic behaviors, cocky-injury, hospitalization, or decease. It should be noted that most individuals do non choose to repeat the experience due to its unpleasant nature.

Please use damage reduction practices if using this substance (e.k. starting with a low dose and always having a trip sitter). Refer to this department for more than details.

Diphenhydramine
Chemical Nomenclature
Common names	DPH, Benadryl, Nytol, Sominex, Unisom SleepMelts, ZzzQuil
Substitutive name	Diphenhydramine
Systematic name	2-(diphenylmethoxy)-North,North-dimethylethanamine
Class Membership
Psychoactive grade	Deliriant / Depressant
Chemical course	Ethanolamine
Routes of Administration
Alarm: Ever kickoff with lower doses due to differences betwixt individual body weight, tolerance, metabolism, and personal sensitivity. See responsible employ department. ⇣ Oral Dosage Bioavailability xl-60% Threshold 25 mg Light 100 - 200 mg Common 200 - 400 mg Potent 400 - 700 mg Heavy 700 mg + Duration Total iii - x hours Onset 30 - 90 minutes Come up up 45 - 90 minutes Peak 1 - 4 hours Outset 2 - 6 hours Afterwards effects upwards to 24 hours DISCLAIMER: Prisoner of war'south dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Diphenhydramine (also known as DPH, Dimedrol, Benadryl, and many others) is a deliriant substance of the ethanolamine grade. Information technology is a first-generation H₁ antihistamine that is widely used as a generic, over-the-counter medication to treat allergies. When exceeding approved doses, diphenhydramine produces powerful deliriant effects.

Diphenhydramine was showtime synthesized in 1943. In 1946, it became the first prescription antihistamine approved by the U.S. Food and Drug Assistants. Information technology was approved for over-the-counter use in the 1980s.^[1] Today, it is typically used to treat allergies, merely it may besides be used for a number of conditions including itchiness, insomnia, movement sickness, nausea and the symptoms of Parkinson's illness.^[2]

Subjective furnishings include sedation, anxiety, tactile hallucinations, memory suppression, thought disorganization, dysphoria, and external hallucinations. Lower doses tend to produce a stoning, body-high effect while higher doses produce a state of delirium in which the user sees and hears fully-formed, extremely convincing hallucinations. Doses betwixt these two extremes are uncomfortable and dysphoric.

Notably, it is oft reported to produce meaning nausea and actual discomfort ("body load"). About users who try diphenhydramine typically do not report positive effects and do not wish to repeat the feel.

It is considered to have low abuse potential owing to its dysphoric furnishings. The toxicity of recreational use is not well-studied. Anecdotal reports suggest that chronic use (i.e. high dose, repeated administration) may cause persisting hallucinations and impairments in cognition & memory. High doses have also been linked to seizures and cardiotoxicity.^[3]

It is highly advised to use harm reduction practices if using this substance.

History and civilization

Diphenhydramine was discovered in 1943 by George Rieveschl, a former professor at the University of Cincinnati.^{[4] [5]} In 1946, it became the first prescription antihistamine approved by the United States Food and Drug Administration (FDA).^[6]

In the 1960s diphenhydramine was plant to inhibit reuptake of the neurotransmitter serotonin.^[7] This discovery led to a search for feasible antidepressants with similar structures and fewer side effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI).^{[7] [8]}

Chemistry

Diphenhydramine, or 2-(diphenylmethoxy)-N,N-dimethylethanamine, is an organic chemical compound belonging to the ethanolamine grade. The chemical construction of diphenhydramine consists of an ethylamine concatenation with two methyl groups bonded to the terminal nitrogen group R_N. Additionally, this ethylamine chain is substituted at R_two with a diphenylmethoxy group, forming an ether. The diphenylmethoxy group consists of two aromatic phenyl rings bonded the carbon member of a methoxy group CH₃O-.

DPH is produced as a hydrochloride salt.

Pharmacology

Diphenhydramine is an inverse agonist of the peripheral histamine H₁ receptor and a primal histamine H₁ receptor.^{[ citation needed ]} The peripheral inverse agonism induces the allergy reducing furnishings.^{[ commendation needed ]} Like many first-generation antihistamines, information technology is also a competitive antagonist at mACH receptors.^{[ citation needed ]}

Diphenhydramine is an acetylcholine receptor antagonist. Although the precise machinery is not understood, the inhibition of the action of acetylcholine is idea to exist primarily responsible for the delirium, sedation and intensely realistic hallucinations alongside the extremely uncomfortable and dysphoric concrete side furnishings.

Diphenhydramine has been shown to cake sodium channels and inhibit the reuptake of serotonin.^{[9] [10]} It also blocks voltage-gated potassium channels (VGKCs), meaning it has the potential to crusade or atomic number 82 to torsades de points, a potentially dangerous cardiac condition that tin lead to sudden cardiac death. ^[eleven]

The receptor binding affinities are listed as follows:^{[12] [13]}

Receptor Site	Bounden Affinity (nM, Lower = Stronger)
H1	nine.6-16
H2	missing information
Hthree	>ten,000
H4	>10,000
One thousandone	lxxx-100
M2	120-490
10003	84-299
Chiliadiv	53-112
1000five	30-260
SERT	≥3,800

Subjective effects

According to user reports, diphenhydramine displays a non-linear dose-response, pregnant the effects don't correspond directly with the dose. Doses under 300 mg are reported to produce restlessness, muscle relaxation, and a body high while doses above 500 mg begin to produce a country of delirium in which the user sees and hears fully-formed, extremely convincing hallucinations. Doses in between these two extremes are said to be uncomfortable and dysphoric. Nausea and actual discomfort ("trunk load") is reported virtually universally.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a outcome, they should be viewed with a healthy degree of skepticism.

Information technology is also worth noting that these furnishings will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of furnishings. Likewise, agin effects become increasingly likely with higher doses and may include addiction, astringent injury, or decease ☠.

• • Sedation - Diphenhydramine produces considerable sedation and low doses are normally used as a sleep aid. This sense of sedation is accompanied by a heavy body load which can become overwhelmingly uncomfortable. Yet, college doses of diphenhydramine also take a stimulating quality that tin can brand actual rest hard.
  • Spontaneous bodily sensations - Users unremarkably report all-encompassing, precipitous and painful jolts of electricity that spontaneously manifest themselves uncontrollably in a similar rhythm to hiccups.
  • Perception of bodily heaviness - One of the most apparent effects is having a massive body as if the gravity has been multiplied tenfold. This makes it extremely tough and uncomfortable to move.
  • Restless leg syndrome - Restless legs are very prominent and arguably 1 of the nearly uncomfortable side furnishings of diphenhydramine. It can besides last for days later on the experience and tin can even be chronic when it is driveling repeatedly.
  • Tactile enhancement - This results in increased feelings of bear upon, pain, warmth and orgasms. It is usually only nowadays at the peak and non during the come up or come down.
  • Tactile suppression - Diphenhydramine produces feelings of numbness throughout the body. This is attributed to its ability to block sodium channels within the nerves.^[14]
  • Tactile hallucination - This is oftentimes a direct result of visual hallucinations and they commonly feel and look as if insects are itch on one's skin.
  • Nausea or Nausea suppression- Depending on the dose, diphenhydramine can both suppress and cause nausea. Low doses effectively suppress nausea, which is why it is marketed and sold equally a motion sickness suppressant, while high doses cause it in significant amounts.
  • Abnormal heartbeat - Diphenhydramine is able to prolong the QT interval, potentially leading to torsades de pointes, an abnormal heart rhythm that tin can cause sudden cardiac death.^[fifteen]
  • Cough suppression ^[16]
  • Aridity ^{[ citation needed ]} - Diphenhydramine tin can be extremely dehydrating, which often leads to dry oral fissure and skin, chapped lips and nose bleeds. Users should drinkable plenty of water before and later an experience.
  • Dizziness
  • Frequent urination & Difficulty urinating - Diphenhydramine has the strange effect of making the user want to frequently urinate while making actual urination extremely difficult. This sensation is described equally very uncomfortable.
  • Gustatory hallucination - A foul metal-like taste is nowadays throughout the entire experience, which in combination with a dry oral cavity can be a very uncomfortable effect that can last for days after the experience. Eating or drinking flavored drinks will only make the taste become away temporarily. It can also announced every bit a sign of addiction, where it acts as a trigger for cravings.
  • Increased blood force per unit area ^{[ citation needed ]} - This ofttimes results in feelings of a beating breast and, with a loftier heart charge per unit can lead to hyperventilation if backlog stress is practical to the trunk.
  • Increased heart charge per unit ^{[ citation needed ]}
  • Increased actual temperature
  • Temperature regulation suppression - This effect can pb the user to experience shivers, especially during the come phase.
  • Increased perspiration
  • Motor control loss
  • Muscle cramps & Musculus spasms - Sudden musculus cramps and spasms tin form unexpectedly. This is common at the outset of the trip and usually passes rapidly.
  • Olfactory hallucination - It is common for users to smell a mild, thick and irksome odour in the air that can easily be ignored most of the time. Some users besides notice a smell enhancement^{[ citation needed ]}
  • Physical fatigue
  • Pupil constriction or Student dilation - While it it shown that diphenhydramine constricts pupils minimally^[17], many people also report that their pupils amplify, especially at high dosages when anti-cholinergic effects take place similar to substances like atropine or scopolamine.
  • Rapid animate
  • Peel flushing - Flushed skin occurs more often than not effectually the eyes, but can also be seen all over the body.
  • Temporary erectile dysfunction
  • Itchiness - This effect happens in high doses, however, it reduces itchiness in lower doses.

• While diphenhydramine produces visual hallucinations, it does non heighten visual stimuli in the manner of psychedelics. Instead, it tends to degrade and subtract visual acuity and processing that results in increased hallucinations and degraded vision. This becomes more apparent in darker areas than in well-lit ones.

  Suppression

  • Double vision- This result is unremarkably present at moderate to high doses of Diphenhydramine making reading incommunicable unless you close one heart.
  • Pattern recognition suppression
  • Visual acuity suppression - This effect tin can result in blurry vision to the point of blindness. It sometimes tin last for days after the experience itself.

  Distortions

  • Drifting (melting, breathing, morphing and flowing) - Compared to hallucinogens, this result can be described as intricate in complexity, jittery and flexible in motion, static in their permanence, realistic in believability, and interactive in plasticity. Information technology is also very faint.
  • Object alteration - The textures seen are described every bit transparent whirling lines and swirls which move at irresolute speeds and jitter uncontrollably. They just announced slightly above surfaces, walls and ceilings and can not be felt.
  • Brightness alteration - Diphenhydramine can cause 1's vision to decrease in effulgence and get dark and gloomy.
  • Visual haze

  Hallucinatory states

  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - Relative to other hallucinogens, this issue occurs more than often at moderate to heavy doses and is the defining feature of the feel. It can exist comprehensively described through its variations every bit delirious in believability, controllable or autonomous in controllability and solid in style. The most mutual themes for these hallucinations include those of both everyday occurrences such as smoking phantom cigarettes, talking to people who are not there, seeing and feeling insects and immersion in sinister or nightmarish experiences.
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - Relative to other hallucinogens, this effect occurs briefly and spontaneously at moderate doses but becomes progressively extended in its occurrence and elapsing proportional to dosage before eventually becoming all-encompassing. Information technology can be comprehensively described through its variations as delirious in believability, interactive in manner, equal in new experiences and retentivity replays in content, autonomous in controllability and solid in style. Internal hallucinations may occur at lighter dosages than needed to cause external hallucinations and delirium.
  • Peripheral information misinterpretation
  • Shadow people
  • Transformations
  • Unspeakable horrors
  • Object activation

• The head space of diphenhydramine is described past many every bit generally negative and dysphoric, often consisting of extreme paranoia and feelings of impending doom. It is extremely confusing and disorienting and often results in a complete inability to communicate or understand normal language.
  • Analysis suppression - At college dosages, a person could feel a consummate halt of external information processing, which can brand the user unable to perform unproblematic tasks or make decisions.
  • Anxiety & Paranoia - Anxiety and paranoia are more commonly reported on diphenhydramine than almost whatever other substance. However, there is a threshold dose (around 500mg) where it begins to disappear.
  • Sleepiness - Diphenhydramine is reported to be extremely tiring. Low doses are often used and sold as a sleep aid.
  • Wakefulness - Even though diphenhydramine is primarily a depressant and causes sleepiness, it has stimulant effects on the trunk, which tin as well keep the user awake. This effect predominates sleepiness at higher dosages.
  • Dysphoria - The levels of dysphoria experienced, however, vary betwixt people with a very minor percentage of users reporting that they do not seem to experience them at all.
  • Cerebral fatigue
  • Confusion - Diphenhydramine causes significant confusion which can event in a complete inability to understand others' intentions, emotions, sense of humor and even simple sentences.
  • Creativity suppression
  • Decreased libido - Interestingly, one'southward sexual practice drive seems to have diminished, although sex and masturbation are considered more enjoyable in a unique way and oft come with powerful orgasms.
  • Delirium - Delirium may be experienced with extremely high doses which may necessitate hospitalization.
  • Delusion
  • Depression
  • Derealization
  • Disinhibition - Disinhibition on diphenhydramine is dissimilar from substances like alcohol, as it may not even be present in sure situations and is heavily influenced by anxiety and paranoia.
  • Dream potentiation - Diphenhydramine is extremely effective at potentiating dreams. This can result in non simply increased intensity but a change in dream content, leading to dreams that are both vivid and extremely bizarre.
  • Dysarthria ^{[ citation needed ]} - Slurred speech and speaking with a different vocalism is common on DPH.
  • Emotion suppression
  • Feelings of impending doom
  • Focus suppression
  • Increased music appreciation
  • Language suppression
  • Memory suppression - Memory suppression on diphenhydramine is extremely strong. Short-term memory loss is affected in a manner similar to cannabis.
    • Amnesia - At college dosages, diphenhydramine can cause a consummate halt of external information processing, which tin can make the user unable to perform unproblematic tasks or make decisions.
  • Motivation suppression - Diphenhydramine tin can crusade a complete loss of motivation to practise almost anything. This is often accompanied past depression and can brand the user extremely bored and restless.
  • Psychosis
  • Thought deceleration
  • Thought disorganization
  • Fourth dimension distortion - Although non extreme, time dilation is definitely felt and can be overwhelming if the user is having a hard trip.

• • Auditory hallucinations - Auditory hallucinations like voices and screams are ordinarily reported on diphenhydramine.
  • Auditory suppression
  • Auditory enhancement

• • Anxiety
  • Brightness amending
  • Cognitive fatigue
  • Dehydration
  • Depression
  • Gustatory hallucination
  • Irritability
  • Motivation suppression
  • Physical fatigue
  • Sleepiness
  • Idea deceleration
  • Visual acuity suppression

Feel reports

Anecdotal reports which describe the effects of this compound within our experience index include:

• Feel: 550mg DPH - My First Time on DPH
• Experience:100/100/100mg, starting time fourth dimension with it
• Feel:300mg DPH + 600mg DXM - An Interesting Philharmonic
• Feel:400mg DXM + 300mg DPH – Bacterial friends
• Experience:550mg-Bugs All Effectually Me.
• Experience:700mg - Joining the 700 society
• Feel:700mg Diphenhydramine trip
• Experience:A combination of tramadol, clonazepam, gabapentin, and dimenhydrinate
• Experience:DPH (750 mg) - The Dancing Invisible Men Come up to Life!
• Experience:DPH 400mg - Barking Paper
• Experience:DXM & DPH in combination
• Feel:Datura & DPH - Results of Experiment past Isopropanol
• Experience:Diphenhydramine (650 mg, Oral) - Midnight walk
• Feel:Nightmare flipping

Boosted feel reports can be found hither:

• Erowid Experience Vaults: Diphenhydramine

Forms

Diphenhydramine is available in several different forms over the counter and online.

• Pills are bachelor over the counter and online. Well-known brands include Benadryl, Benylin, Dramamine, Nytol, Sominex and ZzzQuil. Rarely, some of these products may contain other medicines, including dextromethorphan, guaifenesin, and acetaminophen. Care should exist taken when using these products to ensure that at that place is not an overdose on other medicines in these DPH-containing products.
• Liquid is available over the counter and online. Diphenhydramine in liquid form tin can be taken orally or injected. Well-known brands include Benadryl and ZzzQuil. Rarely, some of these products may incorporate other medicines, including dextromethorphan, guaifenesin, and acetaminophen. Care should be taken when using these products to ensure that there is non an overdose on other medicines in DPH-containing products.
• Powder is bachelor online. Diphenhydramine in powdered form can be taken orally as well as via injection. Any other routes of administration other than oral are non recommended because diphenhydramine burns and dehydrates skin tissue, which leads to extremely painful burns and bleeding.

Dimenhydrinate

Dimenhydrinate (DMH) is a combination drug of Diphenhydramine and viii-Chlorotheophylline^[18], marketed equally Draminate, Dramamine, and Gravol among others, it is used to treat nausea. It is virtually commonly available as tablets, although it is too available in liquid form and as a suppository. In practice, dimenhydrinate is half as potent equally pure diphenhydramine, by weight, dimenhydrinate is between 53% to 55.5% diphenhydramine.^[xix] The improver of the caffeine-like stimulant 8-Chlorotheophylline is reported to increase the dangerous cardiovascular effects diphenhydramine already has alone. This stimulant upshot is also reported to make the trip more than restless and dysphoric, with the added negative of beingness likewise wakeful to sleep the trip away.

Toxicity and harm potential

The toxicity and long-term health furnishings of recreational diphenhydramine employ have not been studied extensively.

User should note that diphenhydramine can be extremely unpredictable and the mechanism past which it produces hallucinations has the potential to outcome in serious injury, hospitalization or death. Additionally, diphenhydramine puts users in a state where they have fiddling command over their actions. Diphenhydramine can provoke bizarre and nonsensical behavior which may put the user at risk.

Anecdotal reports suggest that regular use of diphenhydramine tin have serious effects on one's kidney and bladder with the potential to upshot in issues similar to that of ketamine cystitis.

Cumulative diphenhydramine utilise has been tentatively linked to an increased risk of developing dementia.^[20]

Overdose

The overdose threshold for diphenhydramine is usually held to be around k milligrams; nonetheless, sensitive individuals can overdose with less. The main effects of an overdose are similar to those of heavy doses. Effects include delirium, psychosis, anxiety, confusion also every bit an increased middle rate,^{[ commendation needed ]} increased blood pressure level^{[ citation needed ]}, dryness, urinary memory, dizziness and dilated pupils. Some of the more serious side furnishings at very high doses include the adventure of seizures,^{[ citation needed ]} and dangerous cardiovascular effects such as arrhythmia (aberrant heartbeat).^{[ citation needed ]}

The user may completely not be able to distinguish reality from hallucinations. At that place is also a significant adventure of responding to a delusional environment and perhaps injuring themselves or others and also too much concrete activity which can farther strain the heart or cause rhabdomyolysis.^[21] Individuals undergoing delusions should, if possible, not be agitated. The first lines of treatment for overdose should be benzodiazepines, although medical attending should e'er be sought.

Diphenhydramine tin can get fatal at amounts close to or exceeding 2 grams.^{[ citation needed ]} This tin can consequence in death when combined with about stimulants, depressants and MAOIs.

Psychosis

User reports suggest that diphenhydramine causes psychosis and delirium at a significantly college rate than other hallucinogens (i.e. psychedelics and dissociatives).^{[ commendation needed ]} There are a big number of experience reports online which describe states of psychotic delirium, amnesia, and other serious consequences after abusing the substance. In many cases, it has resulted in hospitalization and decease.^{[ citation needed ]}

The recreational use of diphenhydramine is more often than not non advised. If deciding to employ this substance, 1 should use extreme caution and harm reduction practices, such as having a sober trip sitter.

Dependence and corruption potential

Diphenhydramine produces dependence with chronic use. In comparing to other hallucinogens, DPH has been reported to have significantly less abuse potential than other hallucinogens. This is simply because the vast majority of people who attempt it exercise not wish to repeat the feel.

Tolerance to many of the effects of DPH develops with repeated use. This results in users having to administer increasingly big doses to attain the same effects. After that, it takes about one - ii weeks for tolerance to return to baseline (in the absence of further consumption). DPH presents cross-tolerance with all deliriants, meaning that later the consumption of DPH, all deliriants will have a reduced event.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably prophylactic to use on their ain can suddenly become dangerous or even life-threatening when combined with certain other substances. The following lists some known dangerous interactions (although it is not guaranteed to include all of them).

Always behave independent research (east.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to swallow. Some of the listed interactions take been sourced from TripSit.

• Selective serotonin re-uptake inhibitors (SSRIs) - SSRIs tin can suppress the visual effects of diphenhydramine. However, this combination may drag the run a risk of serotonin syndrome due to diphenhydramine's serotonergic furnishings.^{[ citation needed ]}
• Stimulants - Due to diphenhydramine's excitatory cardiac result, combining it with stimulants poses a hazard of an abnormal middle rhythm, severe tachycardia, or a middle set on every bit well as other cardiovascular events.
• Benzodiazepines - Benzodiazepines can suppress the visual effects of diphenhydramine. However, this tin can combination can produce a dangerous amount of sedation and respiratory low.^{[ commendation needed ]}
• Anticholinergics - Due to diphenhydramine's excitatory cardiac issue, combining it with other anticholinergics poses a risk of an abnormal heart rhythm, severe tachycardia, or a heart attack as well equally other cardiovascular events (inhibition of acetylcholine causes increased middle rate).

Legal condition

Diphenhydramine is available either over the counter or by prescription in most countries. However, some countries require the purchaser to be over 16, 18 or 21.

• Republic of zambia: Diphenhydramine is illegal to possess and sell in Zambia; foreigners have been detained for possession.^{[ commendation needed ]}
• U.s.: Diphenhydramine is widely bachelor over-the-counter in the Us. It is an approved drug and is legal to purchase, possess, and ingest without a license or prescription.^[22]
• Poland: Diphenhydramine is non a controlled substance nether Polish law, but is only bachelor over the counter in medicine that contains paracetamol.<ref>[ii]

See as well

• Responsible employ
• Hallucinogens
• Deliriants
• Antihistamine
• Acetylcholine
• Datura

External links

• Diphenhydramine (Wikipedia)
• Diphenhydramine (Erowid Vault)
• Diphenhydramine (Isomer Blueprint)

References

1. ↑ Emanuel, M. B. (1999). Histamine and the antiallergic antihistamines: a history of their discoveries. Clinical & Experimental Allergy, 29(S3), one-eleven. https://doi.org/x.1046/j.1365-2222.1999.00004.10-i1
2. ↑ http://world wide web.drugs.com/monograph/diphenhydramine-hydrochloride.html
3. ↑ Jang, D. H., Manini, A. F., Trueger, N. South., Duque, D., Nestor, N. B., Nelson, Fifty. S., & Hoffman, R. S. (2010). Condition epilepticus and broad-circuitous tachycardia secondary to diphenhydramine overdose. Clinical Toxicology, 48(ix), 945-948.
4. ↑ Hevesi D (29 September 2007). "George Rieveschl, 91, Allergy Reliever, Dies". The New York Times. Archived from the original on 13 December 2011. Retrieved xiv Oct 2008.
5. ↑ "Benadryl". Ohio History Fundamental. Archived from the original on 5 September 2015. Retrieved xiii August 2015.
6. ↑ Ritchie J (24 September 2007). "UC prof, Benadryl inventor dies". Business Courier of Cincinnati. Archived from the original on 24 December 2008. Retrieved 14 October 2008.
7. ↑ ^{7.0 7.ane} Domino EF (1999). "History of modern psychopharmacology: a personal view with an emphasis on antidepressants". Psychosomatic Medicine. 61 (v): 591–8. doi:x.1097/00006842-199909000-00002. PMID 10511010.
8. ↑ Awdishn RA, Whitmill M, Coba V, Killu K (October 2008). "Serotonin reuptake inhibition by diphenhydramine and concomitant linezolid use can effect in serotonin syndrome". Breast. 134 (4 Meeting abstracts). doi:10.1378/chest.134.4_MeetingAbstracts.c4002.
9. ↑ Domino, E. F. (1999). History of modern psychopharmacology: a personal view with an emphasis on antidepressants. Psychosomatic medicine, 61(5), 591-598.
10. ↑ Kim, Y. S., Shin, Y. K., Lee, C. S., & Song, J. H. (2000). Cake of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain inquiry, 881(2), 190-198.
11. ↑ halifa, 1000., Drolet, B., Daleau, P., Lefez, C., Gilbert, M., Plante, Southward., ... & Turgeon, J. (1999). Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man past the histamine H1 receptor adversary diphenhydramine. Journal of Pharmacology and Experimental Therapeutics, 288(2), 858-865.
12. ↑ https://www.ncbi.nlm.nih.gov/pubmed/11036158
13. ↑ https://world wide web.ncbi.nlm.nih.gov/pubmed/10511010
14. ↑ Cake of sodium currents in rat dorsal root ganglion neurons by diphenhydramine | http://www.sciencedirect.com/scientific discipline/article/pii/S0006899300028602?via%3Dihub
15. ↑ QT interval prolongation in diphenhydramine toxicity | https://www.sciencedirect.com/science/article/abs/pii/S0167527304000786
16. ↑ Antitussive activity of diphenhydramine in chronic cough. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/773581
17. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885114/ | Relationship between sedation and pupillary role: comparing of diazepam and diphenhydramine
18. ↑ Putra, Okky Dwichandra; Yoshida, Tomomi; Umeda, Daiki; Higashi, Kenjirou; Uekusa, Hidehiro; Yonemochi, Etsuo (29 July 2016). "Crystal Structure Determination of Dimenhydrinate after More than 60 Years: Solving Salt–Cocrystal Ambivalence via Solid-State Characterizations and Solubility Study". Crystal Growth & Design. 16 (9): 5223–5229. doi:10.1021/acs.cgd.6b00771.
19. ↑ "Dimenhydrinate injection, solution". Daily Med. U.Due south. National Library of Medicine. Archived from the original on xiii October 2014. Retrieved 19 July 2014.
20. ↑ https://www.ncbi.nlm.nih.gov/pubmed/25621434/
21. ↑ https://pubmed.ncbi.nlm.nih.gov/8857809/
22. ↑ [1]

Source: https://psychonautwiki.org/wiki/Diphenhydramine

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